August 9, 2022Journal of HypertensionOpen Access

Are you as old as your arteries? Comparing arterial aging in Japanese and European patient groups using cardio-ankle vascular index

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Arterial stiffness and cardiovascular risk (n=1538). Intervention: Japanese geographic region (vs European) vs. European geographic region. Primary outcome: Average cardio-ankle vascular index (CAVI) as a predictor of geographic region (OR 1.154, 95% CI 1.013-1.315, p=0.031).

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Key result

Japanese patients exhibited significantly higher arterial stiffness compared to Europeans across age groups, with average CAVI serving as a significant predictor of geographic region (OR 1.154).

Why the study?

Most comparisons of arterial stiffness between ethnic groups focus on pulse wave velocity, leaving CAVI-based assessments of arterial aging across geographic regions underexplored.

Does arterial stiffness (measured by CAVI) and its relationship with age and cardiovascular risk factors differ between Japanese and European individuals?

Population

Four hundred and ninety-four European and 1044 Japanese individuals with 0-5 cardiovascular risk factors

Comparison

European vs Japanese individuals

Design

Cross-sectional comparative study

Authors

FKFrances A. KirkhamBrighton and Sussex Medical School CMCharlotte MillsKing's College London FFFrancesco FantinPreventive Cardiology

Discussion

Member takes

Implication

Ethnic differences in CAVI persist beyond risk factors; leaves open need for ethnicity-specific arterial aging norms.

Study Design

Type

Cross-Sectional (n=1,538)

Multicenter

Yes

Structured PICO

Does arterial stiffness (measured by CAVI) and its relationship with age and cardiovascular risk factors differ between Japanese and European individuals?

Population

1,538 individuals (494 European and 1,044 Japanese) aged 16 to 93 years with varying cardiovascular risk factors underwent cross-sectional assessment of arterial stiffness using the cardio-ankle vascular index.

Outcome

Arterial stiffness measured by cardio-ankle vascular index (CAVI) and its correlation with age and cardiovascular risk factorssurrogate

Main Result

Odds Ratio: 1.154 (95% CI 1.013–1.315)

p-value: p=0.031

Japanese individuals have higher arterial stiffness than Europeans across age groups, but healthy Europeans show a steeper age-related increase in stiffness, highlighting geographic differences in vascular aging.

Limitations

Cross-sectional study design prevents drawing conclusions about causality.
Relatively few participants with no cardiovascular risk factors.
Recruitment methods varied across the different international databanks.
High prevalence of diabetes in the Japanese group, though adjusted for in subgroup analyses.
Differing definitions of BMI between regions based on local guidelines.
Cross-sectional study design prevents drawing conclusions about causality
Relatively few participants with no cardiovascular risk factors
Recruitment methods for each databank varied due to international collaboration
High number of diabetic participants in the Japanese group

Cite This Study

Kirkham et al. (2022) conducted a cross-sectional in Arterial stiffness and cardiovascular risk (n=1,538). Japanese geographic region (vs European) vs. European geographic region was evaluated on Average cardio-ankle vascular index (CAVI) as a predictor of geographic region (OR 1.154, 95% CI 1.013-1.315, p=0.031). Japanese patients exhibited significantly higher arterial stiffness compared to Europeans across age groups, with average CAVI serving as a significant predictor of geographic region (OR 1.154).

synapsesocial.com/papers/6a6d2c40660549caf2c2cd29 https://doi.org/10.1097/hjh.0000000000003214

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August 9, 2022Journal of HypertensionOpen Access

Are you as old as your arteries? Comparing arterial aging in Japanese and European patient groups using cardio-ankle vascular index

View Full Paper

Ask AI

Bookmark

Key result

Japanese patients exhibited significantly higher arterial stiffness compared to Europeans across age groups, with average CAVI serving as a significant predictor of geographic region (OR 1.154).

Why the study?

Most comparisons of arterial stiffness between ethnic groups focus on pulse wave velocity, leaving CAVI-based assessments of arterial aging across geographic regions underexplored.

Does arterial stiffness (measured by CAVI) and its relationship with age and cardiovascular risk factors differ between Japanese and European individuals?

Population

Four hundred and ninety-four European and 1044 Japanese individuals with 0-5 cardiovascular risk factors

Comparison

European vs Japanese individuals

Design

Cross-sectional comparative study

Authors

FKFrances A. KirkhamBrighton and Sussex Medical School CMCharlotte MillsKing's College London FFFrancesco FantinPreventive Cardiology

Discussion

Member takes

Implication

Ethnic differences in CAVI persist beyond risk factors; leaves open need for ethnicity-specific arterial aging norms.

Study Design

Type

Cross-Sectional (n=1,538)

Multicenter

Yes

Structured PICO

Does arterial stiffness (measured by CAVI) and its relationship with age and cardiovascular risk factors differ between Japanese and European individuals?

Population

Outcome

Arterial stiffness measured by cardio-ankle vascular index (CAVI) and its correlation with age and cardiovascular risk factorssurrogate

Main Result

Odds Ratio: 1.154 (95% CI 1.013–1.315)

p-value: p=0.031

Limitations

Cross-sectional study design prevents drawing conclusions about causality.
Relatively few participants with no cardiovascular risk factors.
Recruitment methods varied across the different international databanks.
High prevalence of diabetes in the Japanese group, though adjusted for in subgroup analyses.
Differing definitions of BMI between regions based on local guidelines.
Cross-sectional study design prevents drawing conclusions about causality
Relatively few participants with no cardiovascular risk factors
Recruitment methods for each databank varied due to international collaboration
High number of diabetic participants in the Japanese group

Cite This Study

synapsesocial.com/papers/6a6d2c40660549caf2c2cd29 https://doi.org/10.1097/hjh.0000000000003214

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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