Key result
Transdermal nitroglycerin significantly reduced sitting and standing systolic blood pressures (P<0.05), with a 24 mm Hg mean reduction in subjects with baseline systolic hypertension (P<0.01).
Why the study?
Does transdermal nitroglycerin reduce blood pressure in men with hypertension uncontrolled on a diuretic and beta-blocker?
RCT (n=11)
Double-blind
Crossover
Does transdermal nitroglycerin reduce blood pressure in men with hypertension uncontrolled on a diuretic and beta-blocker?
p-value: p=<0.05
Transdermal nitroglycerin significantly reduced systolic blood pressure when used as a step 3 antihypertensive agent in men with uncontrolled hypertension.
No takes yet. Share an insight, caveat, or question.
Supports transdermal nitroglycerin as step-3 add-on in resistant hypertension; extends nitrate evidence beyond angina.
Simon et al. (1986) conducted an RCT in Hypertension (n=11). Transdermal nitroglycerin vs. Placebo was evaluated on Sitting and standing systolic blood pressures (p=<0.05). Transdermal nitroglycerin significantly reduced sitting and standing systolic blood pressures (P<0.05), with a 24 mm Hg mean reduction in subjects with baseline systolic hypertension (P<0.01).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: