Key result
Regionally specific activated cerebral blood flow measured by the 133Xe technique remained stable across two sessions separated by 9 weeks, demonstrating its reliability.
Why the study?
Is the assessment of regional cerebral blood flow using noninvasive 133Xe techniques reliable and reproducible in elderly normal subjects?
Observational (n=16)
Is the assessment of regional cerebral blood flow using noninvasive 133Xe techniques reliable and reproducible in elderly normal subjects?
The noninvasive 133Xe technique provides reliable and reproducible measurements of regionally specific activated cerebral blood flow over time.
Answers are grounded in this paper and cite their sources.
May limit 133Xe CBF for longitudinal elderly studies; leaves open reproducibility validation.
The assessment of cerebral blood flow (CBF) using noninvasive 133Xe techniques provides an indirect measurement of cortical metabolic activity. The utility of this method in longitudinal clinical studies depends on the stability and reproducibility of resting and activated flow measures. We evaluated CBF in a sample of 16 elderly normal subjects (aged 54-73 years) at rest and during task performance in two sessions separated by an average of 9 weeks. Resting global CBF was lower in the second session, a finding consistent with the known effects of habituation previously reported. Regionally specific activated CBF did not change with repeated measurements. The results provide evidence that the 133Xe technique is reliable and of potential utility in evaluating the effect of the natural course of brain disease, as well as the effects of therapeutic interventions on brain activity.
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Skolnick et al. (1993) conducted an observational in Healthy elderly subjects (n=16). Noninvasive 133Xe technique vs. Repeated measurements (Session 1 vs Session 2) was evaluated on Stability and reproducibility of resting and activated cerebral blood flow. Regionally specific activated cerebral blood flow measured by the 133Xe technique remained stable across two sessions separated by 9 weeks, demonstrating its reliability.
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