Key result
Intravenous infusion of carperitide significantly decreased pulmonary capillary wedge pressure from 21 mmHg to 11 mmHg at 4 hours in patients with refractory heart failure due to severe acute myocardial infarction.
Observational (n=9)
No
Absolute Event Rate: 11% vs 21%
p-value: p=<0.01
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May improve cardiorenal parameters in refractory HF; hypothesis-generating in small Level 5 series, larger trials needed.
Kikuchi et al. (2001) conducted an observational in Refractory heart failure due to severe acute myocardial infarction (n=9). Carperitide vs. Baseline (pre-treatment) was evaluated on Pulmonary capillary wedge pressure (PCWP) at 4 hours (p=<0.01). Intravenous infusion of carperitide significantly decreased pulmonary capillary wedge pressure from 21 mmHg to 11 mmHg at 4 hours in patients with refractory heart failure due to severe acute myocardial infarction.
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