Key result
In patients with hypoxic COPD, infusion of atrial natriuretic peptide selectively reduced right ventricular afterload, lowering mean pulmonary artery pressure from 28.7 to 25.9 mm Hg.
Why the study?
Does atrial natriuretic peptide infusion reduce pulmonary pressures in patients with hypoxic COPD?
Population
10 patients with hypoxic chronic obstructive pulmonary disease (COPD)
Comparison
Atrial natriuretic peptide infused at 0.4, 2… vs Saline infusion for 30 minutes
Design
Other
Follow-up
30-minute periods per dose
Authors
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ANP infusion lowers pulmonary pressure in hypoxic COPD; leaves open whether endogenous ANP protects the circulation or offers therapy.
Does atrial natriuretic peptide infusion reduce pulmonary pressures in patients with hypoxic COPD?
Absolute Event Rate: 25.9% vs 28.7%
ANP infusion selectively reduces right ventricular afterload in patients with hypoxic COPD, suggesting a physiological role in protecting the pulmonary circulation from pressure overload.
Rogers et al. (1994) studied Hypoxic chronic obstructive pulmonary disease (COPD) (n=10). Atrial natriuretic peptide (ANP) vs. Saline was evaluated on Mean pulmonary artery pressure. In patients with hypoxic COPD, infusion of atrial natriuretic peptide selectively reduced right ventricular afterload, lowering mean pulmonary artery pressure from 28.7 to 25.9 mm Hg.
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