Key result
Cloning and expression of rat ether-à-go-go-like K+ channel genes (RELK1 and RELK2) in CHO cells revealed novel voltage-activated potassium currents with distinct activation and inactivation properties.
Population
Rat cortex cDNA and Chinese hamster ovary (CHO) cells
Design
Preclinical
Authors
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Rat elk channel cloning extends brain K+ current mapping; leaves open any human cardiovascular or neurological roles.
The cloning and functional expression of rat elk genes identify novel K+ channels with distinct properties, including HERG-like currents, which may be relevant to cellular electrophysiology.
Engeland et al. (1998) studied this question. Cloning and expression of rat elk genes was evaluated on Functional properties of RELK1 and RELK2 channels. Cloning and expression of rat ether-à-go-go-like K+ channel genes (RELK1 and RELK2) in CHO cells revealed novel voltage-activated potassium currents with distinct activation and inactivation properties.
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