Key result
Minoxidil reduced average supine mean arterial blood pressure from 140 mm Hg on conventional drugs to 106 mm Hg in outpatients with refractory hypertension.
Why the study?
Does minoxidil reduce blood pressure in outpatients with moderate to severe refractory hypertension?
Does minoxidil reduce blood pressure in outpatients with moderate to severe refractory hypertension?
Minoxidil, when combined with propranolol and furosemide to manage side effects, effectively lowers blood pressure in outpatients with refractory hypertension.
Answers are grounded in this paper and cite their sources.
May support outpatient use in refractory hypertension; leaves open need for randomized confirmation.
Minoxidil is a potent orally administered vasodilator under investigation for use in severe hypertension. Fifteen patients with moderate to severe hypertension refractory to conventional antihypertensive drugs were treated with minoxidil on an outpatient basis. Propranolol and furosemide were administered concomitantly to control reflex tachycardia and fluid retention. Good blood pressure control was achieved in all but one patient with the average supine mean arterial blood pressure falling from 140 mm Hg with conventional drugs to 106 mm Hg with minoxidil (P less than 0.0005). The major side effects of fluid retention (9/15), hirsutism (15/15), and tachycardia were adequately controlled in all but one patient. We conclude that minoxidil will be a valuable drug in the outpatient management of refractory hypertension.
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KLEINER et al. (1977) studied moderate to severe hypertension refractory to conventional antihypertensive drugs (n=15). Minoxidil vs. conventional antihypertensive drugs was evaluated on average supine mean arterial blood pressure (p=<0.0005). Minoxidil reduced average supine mean arterial blood pressure from 140 mm Hg on conventional drugs to 106 mm Hg in outpatients with refractory hypertension.
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