Key result
Physical exercise was observed as the common denominator in provoking an arrhythmic phenotype among individuals with familial arrhythmogenic cardiomyopathy variants.
Why the study?
The underlying genetic substrate and clinical course of asymptomatic or oligo-symptomatic mutation carriers in arrhythmogenic cardiomyopathy remain poorly understood.
Does physical exercise provoke an arrhythmic phenotype in patients with familial arrhythmogenic cardiomyopathy mutations?
Observational (n=9)
Does physical exercise provoke an arrhythmic phenotype in patients with familial arrhythmogenic cardiomyopathy mutations?
In familial arrhythmogenic cardiomyopathy, physical exercise acts as a common trigger for arrhythmic phenotypes despite significant variable expressivity among mutation carriers.
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Exercise may modify arrhythmic risk in familial ACM; hypothesis-generating and should not yet change practice.
Costa et al. (2020) conducted an observational in Arrhythmogenic cardiomyopathy (ACM) (n=9). Physical exercise was evaluated on Phenotypic expression profiles / arrhythmic phenotype. Physical exercise was observed as the common denominator in provoking an arrhythmic phenotype among individuals with familial arrhythmogenic cardiomyopathy variants.
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