Key result
MgATP complexes reactivate run-down K+ATP channels in guinea-pig ventricular myocytes via ATP hydrolysis energy, independent of serine/threonine protein kinases.
Population
Guinea-pig ventricular myocytes (inside-out patch configuration)
Comparison
Exposure to MgATP and various ATP… vs Run-down channels without MgATP or exposed to…
Design
Preclinical
Authors
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Does not alter clinical practice; extends mechanistic understanding of K+ATP channel regulation in animal models.
ATP hydrolysis energy, rather than protein phosphorylation, is required for the reactivation of run-down ATP-sensitive K+ channels in guinea-pig ventricular myocytes.
Furukawa et al. (1994) studied this question. MgATP complexes was evaluated on Reactivation of K+ATP channels. MgATP complexes reactivate run-down K+ATP channels in guinea-pig ventricular myocytes via ATP hydrolysis energy, independent of serine/threonine protein kinases.
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