January 1, 1990AJP Heart and Circulatory Physiology

ATP-dependent decay and recovery of K+ channels in guinea pig cardiac myocytes

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Population

Guinea pig cardiac myocytes

Design

Preclinical

Authors

MTMakoto TakanoNational Agriculture and Food Research Organization QDQin DuNorth Sichuan Medical University ANAkinori NomaElectrophysiology

Discussion

Member takes

Implication

ATP dependence in animal myocytes warrants no clinical changes; leaves open human in vivo relevance and therapeutic targeting.

Structured PICO

Population

Guinea pig cardiac myocytes

Intervention

Removal and reapplication of ATP (with Mg2+) using inside-out patch recording and oil-gate concentration jump method

Outcome

Decay and recovery of inward rectifier and ATP-sensitive K+ channelssurrogate

Intracellular ATP and likely phosphorylation are essential for maintaining the activity of inward rectifier and ATP-sensitive K+ channels in cardiac myocytes.

Cite This Study

Takano et al. (1990) studied this question.

synapsesocial.com/papers/6a748af596d04a2f43f5454f https://doi.org/10.1152/ajpheart.1990.258.1.h45

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Bookmark

ATP-dependent decay and recovery of K+ channels in guinea pig cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ATP-dependent decay and recovery of K+ channels in guinea pig cardiac myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider