Key result
Prostaglandin E2 inhibited Na- and Cl-dependent, bumetanide-sensitive K influx in mouse mTAL cells by 45% at nanomolar concentrations, likely by downregulating functioning Na-K-2Cl cotransporters.
Population
Mouse medullary thick ascending limb (mTAL) cells in culture
Design
Preclinical
Authors
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PGE2 inhibits mTAL Na-K-2Cl cotransport in vitro; leaves open its physiologic role in human renal salt handling.
PGE2 inhibits Na-K-2Cl cotransport in mouse mTAL cells by downregulating the number of functioning cotransporters, suggesting tonic inhibitory control.
Kaji et al. (1996) studied this question. Prostaglandin E2 (PGE2) was evaluated on Na- and Cl-dependent, bumetanide-sensitive K influx. Prostaglandin E2 inhibited Na- and Cl-dependent, bumetanide-sensitive K influx in mouse mTAL cells by 45% at nanomolar concentrations, likely by downregulating functioning Na-K-2Cl cotransporters.
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