August 1, 1997AJP Cell Physiology

Prostaglandin E2 increases 7-pS Cl- channel density in the apical membrane of A6 distal nephron cells

View Full Paper

Ask AI

Bookmark

Why the study?

Does prostaglandin E2 increase Cl- channel activity in A6 distal nephron cells?

Population

A6 distal nephron cells

Comparison

Basolateral exposure to prostaglandin E2 vs Baseline/control (no PGE2 exposure)

Design

Preclinical

Authors

KKKenneth E. KokkoJackson Memorial Hospital PMP. S. MatsumotoEmory University ZZZ. R. ZhangJilin University

Discussion

Member takes

Implication

Does not inform clinical practice; leaves open physiologic relevance of PGE2-regulated Cl- channels in mammalian kidney.

Structured PICO

Does prostaglandin E2 increase Cl- channel activity in A6 distal nephron cells?

Population

A6 distal nephron cells

Intervention

Basolateral exposure to prostaglandin E2 (PGE2; peak response at 1 microM)

Comparator

Baseline/control (no PGE2 exposure)

Outcome

Short-circuit current (Isc) and Cl- channel activity/densitysurrogate

Prostaglandin E2 increases amiloride-insensitive short-circuit current in A6 distal nephron cells by increasing the density of functional apical 7-pS Cl- channels.

Cite This Study

Kokko et al. (1997) studied this question.

synapsesocial.com/papers/6a9198c5e771dc7bc3340f3c https://doi.org/10.1152/ajpcell.1997.273.2.c548

View Full Paper

Ask AI

Bookmark

Prostaglandin E2 increases 7-pS Cl- channel density in the apical membrane of A6 distal nephron cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Prostaglandin E2 increases 7-pS Cl- channel density in the apical membrane of A6 distal nephron cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider