Key result
NO donors SNP, SNAP, and SIN-1 exerted cyclic GMP-dependent negative inotropic effects, while SIN-1 and LY 83583 exerted cyclic GMP-independent positive inotropic effects requiring superoxide anion.
Population
Frog atrial and ventricular fibres
Comparison
NO donors vs Baseline or presence of inhibitors (ODQ, SOD)
Design
Preclinical
Authors
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In vitro frog fibre data warrant caution against clinical extrapolation of NO donor inotropy; leaves open cGMP mechanisms in mammalian myocardium.
In frog heart fibres, NO donors exert cyclic GMP-dependent negative inotropic effects via NO generation, while SIN-1 exerts cyclic GMP-independent positive inotropic effects requiring superoxide anion generation.
Chesnais et al. (1999) studied this question. NO donors (SNP, SNAP, SIN-1) was evaluated on Force of contraction. NO donors SNP, SNAP, and SIN-1 exerted cyclic GMP-dependent negative inotropic effects, while SIN-1 and LY 83583 exerted cyclic GMP-independent positive inotropic effects requiring superoxide anion.
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