Key result
During beta-adrenergic stimulation, the change in myofilament Ca2+ sensitivity in 76-week-old spontaneously hypertensive rats (0.65 pCa units) was over twofold greater than in WKY controls (0.30 pCa units).
Population
76-week-old spontaneously hypertensive rats with decompensated cardiac hypertrophy and age-matched…
Comparison
Beta-adrenergic stimulation vs Age-matched Wistar-Kyoto rat controls and…
Design
Preclinical
Authors
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Troponin I hypophosphorylation may impair myofilament function in hypertrophy; leaves open translation to human HF therapies.
Absolute Event Rate: 0.65% vs 0.3%
In decompensated cardiac hypertrophy, a significant decrease in myofilament calcium sensitivity during beta-adrenergic stimulation may contribute to severely impaired inotropic responses.
McConnell et al. (1998) studied Decompensated cardiac hypertrophy. Beta-adrenergic stimulation vs. Wistar-Kyoto rat (WKY) controls was evaluated on Change in myofilament Ca2+ sensitivity during beta-adrenergic stimulation. During beta-adrenergic stimulation, the change in myofilament Ca2+ sensitivity in 76-week-old spontaneously hypertensive rats (0.65 pCa units) was over twofold greater than in WKY controls (0.30 pCa units).
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