Population
32Pi-labeled left ventricular myocytes from hearts of 26-wk spontaneously hypertensive rats and Wistar-Kyoto…
Comparison
Beta-adrenergic stimulation vs Wistar-Kyoto controls (WKY)
Design
Preclinical
Authors
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May underlie blunted beta-adrenergic response in hypertension; hypothesis-generating in rodent model, human relevance unknown.
Increased PKA-dependent TnI phosphorylation in spontaneously hypertensive rats may contribute to impaired myocardial response to sympathetic stimulation.
McConnell et al. (1997) studied this question.
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