September 1, 2001Cardiovascular ResearchOpen Access

Enhanced protein phosphorylation in hypertensive hypertrophy

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Population

Spontaneously hypertensive rats (SHR) (12-13 weeks old) and age-matched normotensive Wistar-Kyoto rats (WKY)

Comparison

Isoproterenol stimulation and assessment of… vs Normotensive Wistar-Kyoto rats (WKY)

Design

Preclinical

Authors

PBPeter Boknı́kUniversity of Münster

Discussion

Member takes

Implication

Attenuated isoproterenol inotropy in SHR hearts should not change practice; leaves open CaMK-PLB contribution to human hypertensive hypertrophy.

Structured PICO

Population

Spontaneously hypertensive rats (SHR) (12-13 weeks old) and age-matched normotensive Wistar-Kyoto rats (WKY)

Intervention

Isoproterenol (Iso) stimulation (3 micromol/l, 10 min) and assessment of cardiac regulatory phosphoproteins

Comparator

Normotensive Wistar-Kyoto rats (WKY)

Outcome

Force of contraction (FOC), Ca2+-uptake by sarcoplasmic reticulum, and protein phosphorylation statessurrogate

In spontaneously hypertensive rats, increased Ca2+/Cam-PK activity and phospholamban phosphorylation enhance SR Ca2+ uptake, potentially contributing to pathophysiological changes in cardiac hypertrophy.

Cite This Study

Peter Boknı́k (2001) studied this question.

synapsesocial.com/papers/6a714a9935aa2c282ce299e6 https://doi.org/10.1016/s0008-6363(01)00346-7

Topics

Hypertension management

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Implication

Attenuated isoproterenol inotropy in SHR hearts should not change practice; leaves open CaMK-PLB contribution to human hypertensive hypertrophy.

Enhanced protein phosphorylation in hypertensive hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Enhanced protein phosphorylation in hypertensive hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider