Key result
A liquid chromatography-tandem mass spectrometry method was validated for determining doxorubicin and its metabolites in mouse plasma, with lower limits of quantification of 0.01 to 0.5 ng/mL.
Why the study?
A method was needed for the simultaneous determination of doxorubicin and its major metabolites in mouse plasma.
A sensitive LC-MS/MS method was successfully developed and validated for the simultaneous quantification of doxorubicin and its four major metabolites in mouse plasma.
No takes yet. Share an insight, caveat, or question.
May advance preclinical doxorubicin studies in mice; leaves open clinical translation.
Choi et al. (2020) studied this question. Doxorubicin was evaluated on Lower limits of quantification and pharmacokinetic determination of doxorubicin and its metabolites. A liquid chromatography-tandem mass spectrometry method was validated for determining doxorubicin and its metabolites in mouse plasma, with lower limits of quantification of 0.01 to 0.5 ng/mL.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: