Key result
Isocratic reversed-phase HPLC method accurately quantifies doxorubicin in human plasma with ~99% recovery.
A rapid and sensitive HPLC method was successfully developed and validated for the quantitative determination of doxorubicin in human plasma.
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May support doxorubicin therapeutic monitoring in research; leaves open clinical adoption pending further validation.
Sripuram et al. (2010) studied this question. HPLC method for doxorubicin determination was evaluated on Method validation (linearity, recovery, precision). An isocratic reversed-phase HPLC method for determining doxorubicin in human plasma was developed and validated, demonstrating linearity (0.2-10 μg/mL), high recovery (98.5-101.1%), and precision.
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