Key result
Patients with psoriasis vulgaris had significantly higher P-wave dispersion (69.1 ms vs 45.6 ms, p<0.001) compared to healthy controls, indicating impaired atrial conduction.
Why the study?
Do patients with psoriasis vulgaris have prolonged P-wave dispersion compared to healthy individuals?
Cross-Sectional (n=119)
No
Do patients with psoriasis vulgaris have prolonged P-wave dispersion compared to healthy individuals?
Absolute Event Rate: 69.1% vs 45.6%
p-value: p=<0.001
Patients with psoriasis vulgaris exhibit prolonged P-wave dispersion, suggesting impaired atrial conduction and a potentially higher risk for developing atrial fibrillation.
PWD prolongation in psoriasis may signal higher AF risk; hypothesis-generating and should not yet change practice.
PURPOSE: Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for the development of AF. The aim of this the study was to investigate P-wave duration and PWD in patients with psoriasis. METHODS: Sixty-one adult patients with psoriasis vulgaris (group 1) and 58 age and sex-matched healthy individuals (group 2) were included in this study. ECG recordings were obtained, and the P-wave variables were calculated. Results were reported as mean ± standard deviation and percentages. Continuous variables were analysed using Student's t test. A value of P < 0.05 was considered statistically significant. RESULTS: Pmax and PWD were significantly higher in group 1 than in group 2 (108.8 ± 21.3 ms versus 93.3 ± 13.0 ms, P < 0.001; 67.4 ± 22.9 ms versus 45.0 ± 19.6 ms, P < 0.001, respectively). Also, Pmin was significantly lower in group 1 (41.3 ± 12.3 ms versus 48.3 ± 14.3 ms, P = 0.04). The psoriasis disease activity score and hsCRP correlated with PWD (P < 0.01). CONCLUSIONS: Atrial conduction of sinus impulses was impaired in patients with psoriasis vulgaris. It was more prominent in patients with severe disease. Physicians caring for patients with psoriasis vulgaris should screen them for AF development.
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Bacaksız et al. (2012) conducted a cross-sectional in Psoriasis vulgaris (n=119). Psoriasis vulgaris vs. Healthy individuals was evaluated on P-wave dispersion (PWD) (p=<0.001). Patients with psoriasis vulgaris had significantly higher P-wave dispersion (69.1 ms vs 45.6 ms, p<0.001) compared to healthy controls, indicating impaired atrial conduction.
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