January 1, 1993Diabetes
Incidence of NIDDM and Impaired Glucose Tolerance in Hypertensive Subjects: The San Antonio Heart Study
Key result
Baseline hypertension was independently associated with an increased 8-year risk of IGT (adjusted OR 1.87; 95% CI 1.08-3.22), but not NIDDM (adjusted OR 0.73; 95% CI 0.34-1.58).
Why the study?
Does hypertension at baseline increase the 8-year incidence of NIDDM and IGT in a general population cohort?
Population
1,471 subjects participating in the San Antonio Heart Study
Comparison
Hypertension at baseline vs Normotensive at baseline
Design
Cohort
Follow-up
8 years
Authors
Discussion
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Implication
Baseline hypertension was associated with higher diabetes incidence; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=1,471)
Structured PICO
Does hypertension at baseline increase the 8-year incidence of NIDDM and IGT in a general population cohort?
P
Population
1,471 subjects from the San Antonio Heart Study followed for 8 years to evaluate the association of baseline hypertension with incident NIDDM and impaired glucose tolerance.
E
Exposure
Hypertension at baseline
C
Comparator
Normotensive at baseline
O
Outcome
8-year incidence of non-insulin-dependent diabetes mellitus (NIDDM) and impaired glucose tolerance (IGT)hard clinical
Main Result
Odds Ratio: 0.73 (95% CI 0.34–1.58)
Absolute Event Rate: 8.9% vs 4.9%
p-value: p=0.041
Hypertension is independently associated with an increased 8-year risk of developing impaired glucose tolerance, but its apparent association with incident NIDDM is explained by confounding metabolic risk factors such as obesity and hyperinsulinemia.
Cite This Study
Morales et al. (1993) conducted a cohort in Hypertension (n=1,471). Hypertension at baseline vs. Normotensive at baseline was evaluated on 8-year incidence of NIDDM (OR 0.73, 95% CI 0.34-1.58, p=0.041). Baseline hypertension was independently associated with an increased 8-year risk of IGT (adjusted OR 1.87; 95% CI 1.08-3.22), but not NIDDM (adjusted OR 0.73; 95% CI 0.34-1.58).