Key result
The SNP rs10743465, located downstream of the SOX5 gene on chromosome 12p11, showed the most significant association with left ventricular mass (beta -0.066, p=1.27E-05).
Observational (n=897)
Mean Difference: -0.066
p-value: p=1.27E-05
Genetic variations on chromosome 12p11, particularly near the SOX5 and TMTC1 genes, are associated with left ventricular mass in Caribbean Hispanics, with TMTC1 showing interaction with abdominal obesity.
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SOX5 variants may influence LVM; supports prior linkage but remains hypothesis-generating pending replication.
Della‐Morte et al. (2011) conducted an observational in Left ventricular mass (n=897). Chromosome 12p11 genetic variants (e.g., rs10743465) vs. Reference alleles was evaluated on Left ventricular mass (natural log transformed) (beta -0.066, p=1.27E-05). The SNP rs10743465, located downstream of the SOX5 gene on chromosome 12p11, showed the most significant association with left ventricular mass (beta -0.066, p=1.27E-05).
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