Key result
The rs7223247 T allele near miR-22 is linked to ~0.27 SD higher LV mass.
Why the study?
Genetic factors accounting for variability in left ventricular mass remain largely unknown, with micro-RNA 22 implicated in cardiac hypertrophy and heart failure in animal models.
Is the rs7223247 polymorphism near miR-22 associated with increased left ventricular mass in families with hypertension?
Observational (n=1,425)
Is the rs7223247 polymorphism near miR-22 associated with increased left ventricular mass in families with hypertension?
Standardized Mean Difference: 0.272
p-value: p=0.038
Common genetic variation at the rs7223247 polymorphism near miR-22 is associated with increased left ventricular mass in hypertensive families, suggesting a potential genetic mechanism for cardiac hypertrophy.
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rs7223247 near miR-22 was associated with higher LVM; hypothesis-generating for genetic regulation of hypertrophy, needing replication before clinical relevance.
Harper et al. (2013) conducted an observational in Left Ventricular Hypertrophy / Hypertension (n=1,425). rs7223247 polymorphism (T allele) vs. rs7223247 polymorphism (G allele) was evaluated on Left ventricular mass determined by Sokolow-Lyon voltage (0.272 SD higher, p=0.038). The T allele at the rs7223247 polymorphism near miR-22 was significantly associated with a 0.272 standard deviation higher left ventricular mass determined by Sokolow-Lyon voltage.
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