Key result
The KCNB1 single-nucleotide polymorphism rs756529 was significantly associated with left ventricular hypertrophy in African Americans (OR 1.40).
Case-Control (n=2,373)
Yes
Odds Ratio: 1.4 (95% CI 1.03–1.92)
p-value: p=0.04
A genome-wide association study identified a single-nucleotide polymorphism in the KCNB1 gene associated with left ventricular mass, suggesting its potential role in the development of left ventricular hypertrophy.
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Should not yet alter LVH risk assessment in African Americans; leaves open causal role and generalizability of KCNB1 variant.
Arnett et al. (2009) conducted a case-control in Left ventricular mass and hypertrophy (n=2,373). KCNB1 single-nucleotide polymorphism (rs756529) vs. Non-carriers / reference alleles was evaluated on Left ventricular hypertrophy (OR 1.40, 95% CI 1.03-1.92, p=0.04). The KCNB1 single-nucleotide polymorphism rs756529 was significantly associated with left ventricular hypertrophy in African Americans (OR 1.40).
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