Key result
Intramyocardial myocd-A gene delivery in 6-day-old piglets transiently decreased LV-end systolic pressure on day 2, which normalized by day 7 post-delivery.
Population
6-day-old neonatal piglets
Comparison
Intramyocardial myocd-A gene delivery vs hop-transfected and control groups
Design
Preclinical
Follow-up
7 days
Authors
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No clinical application in neonates; leaves open myocd-A effects on cardiac performance for further preclinical study.
Torrado et al. (2009) studied Cardiac performance in early neonatal piglets. myocd-A gene delivery vs. hop-transfected and control groups was evaluated on LV-end systolic pressure values. Intramyocardial myocd-A gene delivery in 6-day-old piglets transiently decreased LV-end systolic pressure on day 2, which normalized by day 7 post-delivery.
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