Key result
African swine fever virus protein A238L inhibits NFAT-regulated gene transcription by binding the catalytic subunit of calcineurin and inhibiting its phosphatase activity.
The African swine fever virus protein A238L acts as a viral immunosuppressant by inhibiting calcineurin, similar to the mechanism of cyclosporin A.
Hypothesis-generating in macrophage models; leaves open NFAT inhibition as a target in human viral cardiovascular disease.
The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.
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Miskin et al. (1998) studied African swine fever virus infection. Viral protein A238L was evaluated on Inhibition of NFAT-regulated gene transcription and calcineurin phosphatase activity. African swine fever virus protein A238L inhibits NFAT-regulated gene transcription by binding the catalytic subunit of calcineurin and inhibiting its phosphatase activity.
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