Key result
Serum DNase I activity was significantly higher in patients with acute myocardial infarction (21.7+/-5.10 U/L) compared to those with unstable angina (10.4+/-4.41 U/L) within 3 hours of symptom onset.
Why the study?
Does serum deoxyribonuclease I (DNase I) activity reliably identify acute myocardial infarction in the very early phase after symptom onset compared to other conditions?
Observational
Does serum deoxyribonuclease I (DNase I) activity reliably identify acute myocardial infarction in the very early phase after symptom onset compared to other conditions?
Absolute Event Rate: 21.7% vs 10.4%
Serum DNase I activity peaks abruptly within 3 hours of symptom onset in acute myocardial infarction, suggesting its potential utility as a very early diagnostic biomarker.
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May differentiate early AMI from unstable angina; hypothesis-generating and requires prospective validation before any clinical use.
Kawai et al. (2004) conducted an observational in Acute Myocardial Infarction. Serum deoxyribonuclease I (DNase I) activity vs. Patients with unstable angina pectoris, stable angina pectoris, or other diseases was evaluated on Serum DNase I activity levels within approximately 3 hours of symptom onset. Serum DNase I activity was significantly higher in patients with acute myocardial infarction (21.7+/-5.10 U/L) compared to those with unstable angina (10.4+/-4.41 U/L) within 3 hours of symptom onset.
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