Key result
Ascorbic acid infusion at 24 mg/min significantly improved the forearm blood flow response to methacholine in hypertensive patients (peak response 16.1 vs 12.3 mL/min/dL tissue, P=0.001).
Why the study?
Does intra-arterial ascorbic acid infusion improve endothelial vasomotor function in patients with hypertension?
Does intra-arterial ascorbic acid infusion improve endothelial vasomotor function in patients with hypertension?
Absolute Event Rate: 16.1% vs 12.3%
p-value: p=0.001
High pharmacological concentrations of ascorbic acid are required to improve endothelium-dependent vasodilation in hypertensive patients, suggesting that superoxide anion contributes to endothelial dysfunction in hypertension.
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Pharmacological ascorbic acid may improve endothelial function in hypertension; hypothesis-generating for superoxide role but should not yet change practice.
Sherman et al. (2000) studied Hypertension (n=52). Ascorbic acid vs. Baseline response and normotensive controls was evaluated on Forearm blood flow response to methacholine (p=0.001). Ascorbic acid infusion at 24 mg/min significantly improved the forearm blood flow response to methacholine in hypertensive patients (peak response 16.1 vs 12.3 mL/min/dL tissue, P=0.001).
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