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August 1, 2026CureusOpen Access

Unmasking Factor XIII Deficiency: Recurrent Intracranial Hemorrhage Despite Normal Coagulation Studies

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Authors

KRKarthik RameshGHGavin HuiMSMichael Shodiya

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Overview

Case report shows recurrent intracranial hemorrhage in a patient with unrecognized Factor XIII deficiency, highlighting the need for specific testing.

Key Points

  • This report aims to illustrate the challenges in diagnosing Factor XIII deficiency despite normal coagulation tests.
  • Case report of a 32-year-old man with a history of misdiagnosed von Willebrand disease.
  • Patient was treated with cryoprecipitate for 25 years, masking underlying FXIII deficiency.
  • Subsequent FXIII activity testing confirmed severe deficiency.
  • The patient experienced life-threatening recurrent intracranial hemorrhages after switching to a different treatment.
  • FXIII activity levels were less than 5%, confirming the deficiency.
  • Prophylactic treatment with FXIII concentrate resulted in no further bleeding events.

Cite This Study

Ramesh et al. (2026) studied this question.

synapsesocial.com/papers/6a6d983ee258b358b3c6b530https://doi.org/10.7759/cureus.113621
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