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August 1, 2026Tropical Medicine & International HealthOpen Access

Vaccine Targets and Antimicrobial Resistance of Streptococcus agalactiae Recovered From Pregnant Women in Brazil

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Authors

CBClarissa BarrosFKFabíola C. Oliveira KegeleMSMaria Francisca da S. N. Soares

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Overview

Randomized trial investigates antimicrobial resistance and vaccine targets in pregnant women, suggesting viable immunization options.

Key Points

  • This study aims to investigate the antimicrobial resistance and vaccine targets of Streptococcus agalactiae in pregnant women.
  • Analyzed 222 GBS isolates from pregnant women between 2019 and 2024.
  • Investigated capsular polysaccharides, alpha-like proteins, and antimicrobial susceptibility.
  • Evaluated resistance to macrolides and fluoroquinolones, along with genetic diversity of MDR isolates.
  • Capsular types Ia (35.1%), III (18.9%), and V (17.6%) were prevalent among isolates.
  • Vaccines targeting hexavalent capsular polysaccharides indicated 97.3% efficacy, while alpha-like protein vaccines predicted 87.5% efficacy.
  • 47 erythromycin non-susceptible isolates predominantly showed the M phenotype/mph(A) gene.

Cite This Study

Barros et al. (2026) studied this question.

synapsesocial.com/papers/6a6d98aae258b358b3c6c60bhttps://doi.org/10.1111/tmi.70212
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