Key result
Rechallenge with fluoropyrimidines using cardioprotective pretreatment with calcium channel blockers and long-acting nitrates allowed 100% of patients (11/11) to safely complete chemotherapy.
Why the study?
Does cardioprotective pretreatment with calcium channel blockers and long-acting nitrates allow safe rechallenge of fluoropyrimidines in patients with suspected fluoropyrimidine-induced coronary vasospasm?
Case Report (n=11)
No
Does cardioprotective pretreatment with calcium channel blockers and long-acting nitrates allow safe rechallenge of fluoropyrimidines in patients with suspected fluoropyrimidine-induced coronary vasospasm?
Cardioprotective pretreatment with calcium channel blockers and long-acting nitrates may allow for the safe rechallenge and completion of fluoropyrimidine chemotherapy in patients who previously experienced coronary vasospasm.
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May warrant heightened cardiac monitoring with fluoropyrimidines; leaves open optimal vasospasm prevention strategies.
Clasen et al. (2017) conducted a case report in Fluoropyrimidine-induced coronary vasospasm (n=11). Fluoropyrimidine rechallenge with cardioprotective pretreatment (calcium channel blockers and long-acting nitrates) was evaluated on Successful continuation and completion of planned chemotherapy regimen without cardiac events or recurrent coronary spasm. Rechallenge with fluoropyrimidines using cardioprotective pretreatment with calcium channel blockers and long-acting nitrates allowed 100% of patients (11/11) to safely complete chemotherapy.
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