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Review candidate surface and molecular markers for assessing MSC potency and isolating uncultured native bone marrow stromal cells for regenerative therapies.

January 1, 2012Stem Cells InternationalOpen Access

Markers for Characterization of Bone Marrow Multipotential Stromal Cells

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Review candidate surface and molecular markers for assessing MSC potency and isolating uncultured native bone marrow stromal cells for regenerative therapies.
Assessed surface and molecular markers correlated with MSC proliferation and multilineage differentiation potential.
Evaluated prospective isolation markers for native, uncultured bone marrow MSCs across human and comparative animal models.
Purity and potency assays for therapeutic, culture-expanded MSC batches remain largely rudimentary despite widespread clinical use.
Cross-reactive surface markers, notably CD271 and W8-B2/MSCA-1, demonstrate the highest translational utility for prospective MSC isolation across small and large animal models.

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Implication

Narrative review evaluates potency and prospective isolation markers for bone marrow multipotential stromal cells, highlighting the translational value of cross-reactive markers like CD271.

Cite This Study

Boxall et al. (2012) studied this question.

synapsesocial.com/papers/6a6dd342e36a167817e03465 https://doi.org/10.1155/2012/975871

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Implication

Narrative review evaluates potency and prospective isolation markers for bone marrow multipotential stromal cells, highlighting the translational value of cross-reactive markers like CD271.

Markers for Characterization of Bone Marrow Multipotential Stromal Cells

Key Points

Discussion

Implication

Cite This Study

Markers for Characterization of Bone Marrow Multipotential Stromal Cells

Key Points

Discussion

Implication

Cite This Study

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