Type I diabetes in normotensive, normoalbuminuric subjects was associated with a significantly higher prevalence of non-dipping blood pressure compared to healthy controls (38.5% vs 0%, P<0.05).
Case-Control (n=27)
Do normotensive, normoalbuminuric subjects with type I diabetes have impaired day-night blood pressure variation compared to healthy volunteers?
Ambulatory BP monitoring reveals that normotensive, normoalbuminuric patients with type I diabetes frequently exhibit an impaired nocturnal BP fall (non-dipping pattern), potentially increasing their risk for complications.
Tasa de eventos absoluta: 38.5% vs 0%
valor p: p=< 0.05
OBJECTIVE: To examine day-night blood pressure (BP) variation in normotensive, normoalbuminuric subjects with type I diabetes and to assess the prevalence of an impaired nocturnal BP fall. RESEARCH DESIGN AND METHODS: Fourteen healthy volunteers and 13 normotensive, normoalbuminuric subjects with type I diabetes were studied with an ambulatory sphygmomanometric device for 24 h. RESULTS: No significant difference was found between diabetic and control groups with regard to daytime systolic blood pressure (sBP) or diastolic blood pressure (dBP). However, the mean nighttime sBPs (P < 0.01) and dBPs (P = 0.01) were significantly higher in the diabetic group compared with the control group. Furthermore, the night/day ratio for both sBP (P < 0.01) and dBP (P < 0.01) was significantly higher in the diabetic group. Approximately half of the diabetic subjects studied were non-dippers when defined either by a nocturnal fall in sBP/dBP of < 10/5 mmHg (5/13 vs. 0/14, P < 0.05: diabetic group vs. control group) or a day to night fall in either sBP (7/13 vs. 2/14, P < 0.05) or dBP (6/13 vs. 0/14, P < 0.01) of < 10%. CONCLUSIONS: Ambulatory BP may reveal impaired nocturnal BP fall in normotensive, normoalbuminuric subjects with type I diabetes. These subjects may be at greater risk of certain complications as a consequence of an increased BP burden.
Gilbert et al. (Mon,) conducted a case-control in Type I diabetes (n=27). Type I diabetes vs. Healthy volunteers was evaluated on Non-dipping status (nocturnal fall in sBP/dBP of < 10/5 mmHg) (p=< 0.05). Type I diabetes in normotensive, normoalbuminuric subjects was associated with a significantly higher prevalence of non-dipping blood pressure compared to healthy controls (38.5% vs 0%, P<0.05).