What question did this study set out to answer?

To determine the prevalence of impaired nocturnal blood pressure fall in adolescents with type 1 diabetes who are normotensive and normoalbuminuric.

June 1, 1996Diabetic Medicine

Diurnal Variation of Blood Pressure in Adolescents with Type 1 Diabetes: Dippers and Non-dippers

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Why the study?

Do normotensive adolescents with Type 1 diabetes have an impaired nocturnal blood pressure fall compared to healthy controls?

Key Points

To determine the prevalence of impaired nocturnal blood pressure fall in adolescents with type 1 diabetes who are normotensive and normoalbuminuric.
Evaluated 36 normotensive, normoalbuminuric adolescents with type 1 diabetes (mean age 14.4 ± 2.1 years) and 23 healthy controls (mean age 15.0 ± 1.6 years).
Measured 24-hour blood pressure using an ambulatory monitor at 30-minute daytime and 60-minute nighttime intervals synchronized to patient sleep diaries.
Daytime and nighttime systolic and diastolic blood pressure levels and overall variability showed no significant differences between diabetic patients and controls.
Significantly more diabetic adolescents were non-dippers (<10% nocturnal drop) than controls (15/36 [41.7%] vs. 3/23 [13.0%]; chi-squared = 5.43, p < 0.02), driven predominantly by impaired systolic dipping (13/36).

Structured PICO

Do normotensive adolescents with Type 1 diabetes have an impaired nocturnal blood pressure fall compared to healthy controls?

Population

36 normoalbuminuric normotensive adolescents with Type 1 diabetes (mean age 14.4 +/- 2.1 years, 19 males, 17 females) and 23 healthy controls (mean age 15.0 +/- 1.6 years, 11 males, 12 females).

Comparator

Healthy controls

Outcome

Prevalence of impaired nocturnal blood pressure fall (non-dippers, defined as a nocturnal fall in either systolic or diastolic BP or both of less than 10%)surrogate

A significant proportion of normotensive adolescents with Type 1 diabetes exhibit an impaired nocturnal fall in blood pressure, which may precede long-term vascular complications.

Discussion

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Implication

Non-dipping may be more common in normotensive T1D adolescents; hypothesis-generating for early vascular risk before practice change.

Cite This Study

Khan et al. (1996) studied this question.

synapsesocial.com/papers/6a9070563de278877b83fbde https://doi.org/10.1002/(sici)1096-9136(199606)13:6<531::aid-dia115>3.0.co;2-j

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Diurnal Variation of Blood Pressure in Adolescents with Type 1 Diabetes: Dippers and Non-dippers

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Diurnal Variation of Blood Pressure in Adolescents with Type 1 Diabetes: Dippers and Non-dippers

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider