Key result
Humoral immunity, demonstrated by antibody production or antiserum injection, significantly increased the severity and prevalence of obstructive coronary lesions in transplanted mouse hearts (p<0.0003).
Why the study?
Does humoral immunity drive the development of obstructive coronary lesions in transplanted mouse hearts?
Population
Inbred mice receiving heart transplants after brief preoperative immunosuppression with mAbs to CD4 and CD8
Comparison
Transplantation between strains producing… vs Transplantation between strains not producing…
Design
Preclinical
Authors
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Should not yet alter transplant immunosuppression; leaves open humoral immunity as a target in human cardiac allograft vasculopathy.
Does humoral immunity drive the development of obstructive coronary lesions in transplanted mouse hearts?
p-value: p=< 0.0003
Humoral immunity plays a primary role in the development of atheromatous changes and obstructive coronary lesions in transplanted hearts.
Russell et al. (1994) studied Coronary atherosclerosis in transplanted hearts. Antiserum against donor antigens vs. No antiserum / strains not producing antibodies to donor cells was evaluated on Severity and prevalence of obstructive coronary lesions (p=< 0.0003). Humoral immunity, demonstrated by antibody production or antiserum injection, significantly increased the severity and prevalence of obstructive coronary lesions in transplanted mouse hearts (p<0.0003).
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