Key result
Treatment with R4-6A2, a monoclonal antibody to IFN-gamma, strikingly inhibited the formation of obstructive vascular lesions in transplanted mouse hearts (P<0.0001 for class I incompatibility).
Why the study?
Does continuing treatment with an mAb to IFN-gamma prevent the formation of obstructive vascular lesions in transplanted mouse hearts?
Population
Mouse hearts transplanted to recipients incompatible for either class I or class II antigens, after brief…
Design
Preclinical
Follow-up
4 weeks
Authors
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Recipient immune cells drive obstructive lesions in this murine transplant model; leaves open translation to human cardiac allograft vasculopathy.
Does continuing treatment with an mAb to IFN-gamma prevent the formation of obstructive vascular lesions in transplanted mouse hearts?
p-value: P < 0.0001 for class I and P < 0.03 for class II
Inhibition of IFN-gamma significantly reduces the formation of obstructive coronary vascular lesions in a mouse model of heart transplantation.
Russell et al. (1994) studied Obstructive coronary arterial lesions in transplanted hearts. R4-6A2 (mAb to IFN-gamma) was evaluated on Formation of obstructive vascular lesions (p=P < 0.0001 for class I and P < 0.03 for class II). Treatment with R4-6A2, a monoclonal antibody to IFN-gamma, strikingly inhibited the formation of obstructive vascular lesions in transplanted mouse hearts (P<0.0001 for class I incompatibility).
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