Key result
Interleukin-4 completely neutralized the downregulation of thrombomodulin activity induced by pyrogens (IL-1, TNF, LPS) in cultured human vascular endothelial cells.
Why the study?
Does IL-4 counteract pyrogen-induced downregulation of thrombomodulin in cultured human vascular endothelial cells?
Does IL-4 counteract pyrogen-induced downregulation of thrombomodulin in cultured human vascular endothelial cells?
IL-4 protects human vascular endothelial cells against pyrogen-induced procoagulant changes by counteracting the downregulation of thrombomodulin.
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IL-4 may attenuate endothelial procoagulant shift in vitro; leaves open any role in inflammatory thrombosis.
Kapiotis et al. (1991) studied this question. Interleukin-4 vs. Pyrogen alone (IL-1, TNF, LPS) was evaluated on Thrombomodulin (TM) activity and mRNA expression. Interleukin-4 completely neutralized the downregulation of thrombomodulin activity induced by pyrogens (IL-1, TNF, LPS) in cultured human vascular endothelial cells.
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