Why the study?
Does interleukin-4 reduce TNF-alpha induced expression of tissue factor and PAI-1 in human umbilical vein endothelial cells?
Does interleukin-4 reduce TNF-alpha induced expression of tissue factor and PAI-1 in human umbilical vein endothelial cells?
IL-4 inhibits TNF-alpha-induced pro-coagulant tissue factor expression but not anti-fibrinolytic PAI-1 production in human endothelial cells, suggesting a specific regulatory role in vascular inflammation.
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IL-4 selectively inhibits endothelial TF expression in vitro; hypothesis-generating for vascular inflammation modulation, requiring in vivo confirmation before any clinical consideration.
Martin et al. (1993) studied this question.
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