Why the study?
Do TNF-alpha and IL-1beta downregulate ACE expression in cultured human endothelial cells?
Do TNF-alpha and IL-1beta downregulate ACE expression in cultured human endothelial cells?
TNF-alpha and IL-1beta downregulate ACE in human endothelial cells via the p38 MAPK pathway, suggesting a potential counterbalancing mechanism in inflammatory processes such as atherosclerosis.
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In vitro cytokine effects on endothelial ACE leave open any role in human atherosclerosis; prospective in vivo studies needed.
Saijonmaa et al. (2001) studied this question.
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