Why the study?
Do tumor necrosis factor (TNF) and interleukin-1 (IL-1) stimulate renin secretion in rat renal cortical slices?
Population
Rat renal cortical slices
Comparison
Recombinant and purified tumor necrosis factor… vs Control (untreated slices)
Design
Preclinical
Authors
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May indicate cytokine effects on renin release in vitro; leaves open relevance to human RAS or disease.
Do tumor necrosis factor (TNF) and interleukin-1 (IL-1) stimulate renin secretion in rat renal cortical slices?
TNF and IL-1 stimulate renin secretion and block the inhibitory effects of angiotensin-II, indicating a potential paracrine role in regulating the renin-angiotensin system.
Antonipillai et al. (1990) studied this question.
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