Population
As4.1 cell line (established from a mouse kidney tumor by transgene-targeted tumorogenesis)
Design
Preclinical
Authors
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IL-1 transcriptional suppression of renin may underlie blunted RAS activation in septic shock; leaves open relevance in human critical illness.
Interleukin-1 downregulates renin synthesis at the transcriptional level, providing a potential mechanism for the lack of renin-angiotensin system activation during septic shock.
Petrović et al. (1997) studied this question.
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