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August 6, 2012Journal of the Science of Food and AgricultureOpen Access

Analysis of 100 Belgium beers using G12/A1 monoclonal antibodies estimated at least 20 ppm gluten equivalents in 90 beers and found 10 beers to be gluten-free.

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Population

100 Belgium beers

Design

Other

Key result

Analysis of 100 Belgium beers using G12/A1 monoclonal antibodies estimated at least 20 ppm gluten equivalents in 90 beers and found 10 beers to be gluten-free.

Authors

ICIsabel CominoARAna RealMMMaría de Lourdes Moreno

Discussion

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Member takes

Overview

Beers may retain immunotoxic gluten peptides; leaves open safe consumption thresholds for celiac patients and needs clinical validation.

Structured PICO

P
Population
100 Belgium beers analyzed for the presence of gluten peptides equivalent to the major immunotoxic protease-resistant gliadin 33-mer.
E
Exposure
Immunological determination of gliadin 33-mer equivalent peptides using monoclonal antibodies (G12/A1)
O
Outcome
Presence of gluten peptides equivalent to gliadin 33-mer

The G12/A1 monoclonal antibody method is a practical and specific way to measure potential immunotoxicity of beers for celiac patients.

Cite This Study

Comino et al. (2012) studied Celiac disease (n=100). Immunological determination of gliadin 33-mer equivalent peptides was evaluated on Presence of gluten peptides equivalent to gliadin 33-mer. Analysis of 100 Belgium beers using G12/A1 monoclonal antibodies estimated at least 20 ppm gluten equivalents in 90 beers and found 10 beers to be gluten-free.

synapsesocial.com/papers/6a6dfe8778a11c550e08387ahttps://doi.org/10.1002/jsfa.5830
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification and In Vitro Reactivity of Celiac Immunoactive Peptides in an Apparent Gluten-Free Beer2014 · 42 citations
  2. 2Immunogenic Potential of Beer Types Brewed With Hordeum and Triticum spp. Malt Disclosed by Proteomics2020 · 12 citations
  3. 3Characteristics and Immunogenicity of Gluten Peptides in Enzyme-Treated and -Untreated Beers for Celiac Patients2024 · 4 citations
  4. 4Gluten in Beers: Evaluation of Reproducibility of the R5-Based Competitive Enzyme-Linked Immunosorbent Assay Method Using Real Samples2024
  5. 5Identification of celiac disease-active peptides in gluten-free barley beers by nanoLC-MS/MS2026