Key result
Cell-free translation of human mRNA showed that eight snRNP proteins are encoded by separate messages, with Sm autoimmune sera recognizing all eight proteins and RNP sera recognizing only two.
Population
Cell-free translation system using human poly(A)+ RNA and sera from patients with systemic lupus erythematosus
Design
Preclinical
Authors
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Does not alter autoantibody testing in connective tissue disease; leaves open whether separate snRNP mRNAs shape Sm/RNP autoimmunity.
The study demonstrates that human snRNP proteins are encoded by separate mRNAs and can undergo post-translational assembly in a cell-free system, identifying specific antigenic targets for autoimmune sera.
Fisher et al. (1983) studied Systemic lupus erythematosus. Cell-free translation was evaluated on snRNP protein identification and assembly. Cell-free translation of human mRNA showed that eight snRNP proteins are encoded by separate messages, with Sm autoimmune sera recognizing all eight proteins and RNP sera recognizing only two.
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