Key result
Passenger CD4 T cells within heart transplants contribute to allograft vasculopathy by providing help to recipient B cells for autoantibody generation.
Why the study?
Do donor CD4 T cells contribute to cardiac allograft vasculopathy by providing help for autoantibody production in a mouse model?
Population
Mouse model of heart allograft vasculopathy (bm12 heart grafts into C57BL/6 recipients)
Comparison
Depletion of donor CD4 T cells before heart… vs Standard bm12 into C57BL/6 heart transplantation
Design
Preclinical
Follow-up
50 days
Authors
Loading...
Should not alter clinical transplant management; animal data leaves open passenger CD4 T-cell targeting for human allograft vasculopathy.
Do donor CD4 T cells contribute to cardiac allograft vasculopathy by providing help for autoantibody production in a mouse model?
Passenger CD4 T cells within heart transplants contribute to allograft vasculopathy by helping recipient B cells generate autoantibodies.
Win et al. (2009) studied Heart allograft vasculopathy. Donor CD4 T cells vs. Depletion of donor CD4 T cells or B-cell deficient recipients was evaluated on Development of antinuclear autoantibody and humoral vascular changes. Passenger CD4 T cells within heart transplants contribute to allograft vasculopathy by providing help to recipient B cells for autoantibody generation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: