What question did this study set out to answer?

To assess the diagnostic value of PIVKAII and GGTII as complementary serum tumor markers to alpha-fetoprotein for detecting hepatocellular carcinoma.

June 1, 2003British Journal of CancerOpen Access

Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to α-fetoprotein

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Authors

RCRutao CuiZhejiang University JHJianhong He FZF ZhangBeijing Friendship Hospital

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Implication

Diagnostic study demonstrates enhanced tumor detection from combined PIVKA-II, GGT-II, and AFP in liver disease, suggesting improved diagnostic sensitivity for hepatocellular carcinoma.

Key Points

To assess the diagnostic value of PIVKAII and GGTII as complementary serum tumor markers to alpha-fetoprotein for detecting hepatocellular carcinoma.
Measured serum concentrations of PIVKAII, GGTII, and AFP in 120 patients with hepatocellular carcinoma (including 32 small HCC cases) and 90 patients with cirrhosis.
Evaluated individual diagnostic sensitivity and the performance of combined multi-marker panels.
PIVKAII above 40 mAU ml(-1) was detected in 53.3% (64/120) of total HCC cases and 40.6% (13/32) of small HCC cases, compared to 14.4% (13/90) of cirrhosis controls.
Positive GGTII was identified in 74.0% (89/120) of HCC cases and 43.8% (14/32) of small HCC cases versus 17.8% (16/90) in cirrhosis, while AFP (>20 ng ml(-1)) was elevated in 58.3% (70/120) of HCC and 36.7% (33/90) of cirrhosis controls.
No significant correlation was found between AFP and PIVKAII levels, and combining PIVKAII, AFP, and GGTII significantly increased sensitivity over AFP alone.

Cite This Study

Cui et al. (2003) studied this question.

synapsesocial.com/papers/6a6e179526770c2b8ddfb680 https://doi.org/10.1038/sj.bjc.6601018

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Implication

Diagnostic study demonstrates enhanced tumor detection from combined PIVKA-II, GGT-II, and AFP in liver disease, suggesting improved diagnostic sensitivity for hepatocellular carcinoma.

Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to α-fetoprotein

Discussion

Member takes

Implication

Key Points

Cite This Study

Diagnostic value of protein induced by vitamin K absence (PIVKAII) and hepatoma-specific band of serum gamma-glutamyl transferase (GGTII) as hepatocellular carcinoma markers complementary to α-fetoprotein

Discussion

Member takes

Implication

Key Points

Cite This Study

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