Key result
Regular aspirin use was associated with an increased risk of developing Crohn's disease (OR 6.14; 95% CI 1.76-21.35), but not ulcerative colitis.
Why the study?
Does regular aspirin use increase the risk of developing Crohn's disease or ulcerative colitis in adults aged 30-74 years?
Population
135,780 men and women in Europe, aged 30-74 years, recruited into the European Prospective Investigation…
Comparison
Regular aspirin use vs No regular aspirin use (matched controls)
Design
Cohort
Authors
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May warrant aspirin caution in IBD-prone patients; leaves open causality and need for confirmatory trials.
Cohort (n=135,780)
Yes
Does regular aspirin use increase the risk of developing Crohn's disease or ulcerative colitis in adults aged 30-74 years?
Odds Ratio: 6.14 (95% CI 1.76–21.35)
Regular aspirin use is strongly associated with an increased risk of developing Crohn's disease, but not ulcerative colitis, in a European cohort.
Chan et al. (2011) conducted a cohort in Crohn's disease and ulcerative colitis (n=135,780). Regular aspirin use vs. No regular aspirin use was evaluated on Development of Crohn's disease (OR 6.14, 95% CI 1.76-21.35). Regular aspirin use was associated with an increased risk of developing Crohn's disease (OR 6.14; 95% CI 1.76-21.35), but not ulcerative colitis.
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