Why the study?
Current practice typically uses a single drug, leaving unclear whether dual antiplatelet therapy with aspirin and clopidogrel reduces recurrent stroke and death more than aspirin alone after high-risk transient ischaemic attack or minor ischaemic stroke.
Does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction in recurrent stroke and death over the use of aspirin alone when given in the first 24 hours after a high risk transient ischaemic attack or minor ischaemic stroke?
Does dual antiplatelet therapy with a combination of aspirin and clopidogrel lead to a greater reduction in recurrent stroke and death over the use of aspirin alone when given in the first 24 hours after a high risk transient ischaemic attack or minor ischaemic stroke?
A clinical practice guideline strongly recommends initiating dual antiplatelet therapy (aspirin and clopidogrel) within 24 hours of high-risk TIA or minor stroke and continuing for 10-21 days to reduce recurrent stroke and death.
Strong recommendation supports early aspirin-clopidogrel after high-risk TIA or minor stroke; reinforces randomized evidence in updated guidance.
What Is the Role of Dual Antiplatelet Therapy After High Risk Transient Ischaemic Attack or Minor Stroke? Specifically, Does Dual Antiplatelet Therapy With a Combination of Aspirin and Clopidogrel Lead to a Greater Reduction in Recurrent Stroke and Death Over the Use of Aspirin Alone When Given in the First 24 Hours After a High Risk Transient Ischaemic Attack or Minor Ischaemic Stroke? An Expert Panel Produced a Strong Recommendation for Initiating Dual Antiplatelet Therapy Within 24 Hours of the Onset of Symptoms, and for Continuing It for 10-21 Days Current Practice Is Typically to Use a Single Drug.
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Prasad et al. (2018) studied acute high risk transient ischaemic attack and minor ischaemic stroke. Dual antiplatelet therapy with aspirin and clopidogrel vs. aspirin alone was evaluated on recurrent stroke and death. An expert panel strongly recommends initiating dual antiplatelet therapy with aspirin and clopidogrel within 24 hours of symptom onset and continuing for 10-21 days for high-risk TIA or minor stroke.
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