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April 1, 1999JCR Journal of Clinical Rheumatology

Endomyocardial biopsy successfully diagnosed cardiac involvement in a patient with Churg-Strauss syndrome and confirmed the resolution of inflammation after 1 month of high-dose prednisone.

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Why the study?

Is endomyocardial biopsy a safe and useful tool in the diagnosis and monitoring of therapy in patients with Churg-Strauss syndrome cardiac disease?

Population

73-year-old man presenting with signs and symptoms of an acute myocardial infarction, eosinophilia, a…

Design

Case_report

Follow-up

1 month

Key result

Endomyocardial biopsy successfully diagnosed cardiac involvement in a patient with Churg-Strauss syndrome and confirmed the resolution of inflammation after 1 month of high-dose prednisone.

Authors

WCWarner CarrAsthma AssociationSOSteven A. OlderUnited States Army Medical CommandWRWilliam RollefsonArkansas Heart Hospital

Discussion

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Overview

May support endomyocardial biopsy for cardiac EGPA diagnosis and response monitoring; leaves open need for prospective validation.

Study Design

Type

Case Report (n=1)

Structured PICO

Is endomyocardial biopsy a safe and useful tool in the diagnosis and monitoring of therapy in patients with Churg-Strauss syndrome cardiac disease?

P
Population
A 73-year-old man with Churg-Strauss syndrome presenting with signs of an acute myocardial infarction.
I
Intervention
Endomyocardial biopsy for diagnosis and monitoring, followed by high dose prednisone therapy.
O
Outcome
Histological findings on endomyocardial biopsy (eosinophilic myositis, granuloma formation, and small vessel vasculitis) and response to therapy.surrogate

Endomyocardial biopsy is a safe and useful tool for diagnosing and monitoring cardiac involvement in Churg-Strauss syndrome.

Cite This Study

Carr et al. (1999) conducted a case report in Churg-Strauss syndrome (n=1). Endomyocardial biopsy and high dose prednisone therapy was evaluated on Evidence of inflammation and fibrosis on repeat biopsy. Endomyocardial biopsy successfully diagnosed cardiac involvement in a patient with Churg-Strauss syndrome and confirmed the resolution of inflammation after 1 month of high-dose prednisone.

synapsesocial.com/papers/6a6e3a672163a0a01bc322b1https://doi.org/10.1097/00124743-199904000-00008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Churg–Strauss syndrome presenting with eosinophilic myocarditis: A diagnostic challenge2013 · 10 citations
  2. 2Cardiac magnetic resonance demonstrates the three-layer involvement in Churg–Strauss syndrome2008 · 5 citations
  3. 3Churg–Strauss syndrome presenting with eosinophilic myocarditis: A diagnostic challenge2013 · 2 citations
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