Key result
Concurrent use of a nicotine patch and cigarette smoking was associated with the onset of angina pectoris and a subsequent myocardial infarction in a reported patient case.
Why the study?
Does concurrent use of a nicotine patch and smoking cause myocardial infarction?
Does concurrent use of a nicotine patch and smoking cause myocardial infarction?
Concurrent use of a nicotine patch and smoking may precipitate angina and myocardial infarction due to nicotine's effects on coronary vasomotricity.
Answers are grounded in this paper and cite their sources.
May signal interaction risk with concurrent nicotine patch and smoking; hypothesis-generating and should not yet change practice.
A case of angina pectoris revealed by nicotine patch treatment is described in a patient who continued to smoke and subsequently suffered a myocardial infarction. The various side effects of nicotine and its derivatives are recalled. The action of nicotine on coronary vasomotricity and its mediators is discussed.
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Dacosta et al. (1993) studied this question. Concurrent use of a nicotine patch and cigarette smoking was associated with the onset of angina pectoris and a subsequent myocardial infarction in a reported patient case.
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