Key result
Temocapril treatment in hypertensive patients with impaired glucose tolerance yielded greater reductions in left ventricular mass index (-15.1% vs -11.4%) than in those with normal glucose tolerance.
Why the study?
Does temocapril treatment improve left ventricular hypertrophy and diastolic function in relation to insulin resistance in essential hypertensive patients?
Observational (n=83)
Open-label
Does temocapril treatment improve left ventricular hypertrophy and diastolic function in relation to insulin resistance in essential hypertensive patients?
Absolute Event Rate: -15.1% vs -11.4%
Insulin resistance is an important factor affecting left ventricular hypertrophy and diastolic function in hypertensive patients, and its improvement with ACE inhibition correlates with cardiac structural and functional improvements.
No takes yet. Share an insight, caveat, or question.
Should not yet change ACEI selection by glucose tolerance; leaves open differential LV remodeling effects in hypertension.
Watanabe et al. (1999) conducted an observational in Essential hypertension (n=83). Temocapril vs. Hypertensive patients with normal glucose tolerance (NGT-HT) was evaluated on Changes in left ventricular mass index (D-LVMI; %). Temocapril treatment in hypertensive patients with impaired glucose tolerance yielded greater reductions in left ventricular mass index (-15.1% vs -11.4%) than in those with normal glucose tolerance.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: