Key result
Folate supplementation in pregnant women protects against congenital heart defects and low birth weight, but no RCTs support doses higher than the recommended 400-800 µg/d.
Why the study?
It is unclear whether the prevention time window for congenital heart defects matches neural tube defects, and RCT evidence is lacking regarding whether high-dose folic acid is more effective than currently recommended doses.
Does folate supplementation prevent congenital heart defects and low birth weight in pregnant women?
Comparison
Folic acid in mg/d range vs currently recommended 400-800 µg/d
Design
Review
Authors
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Supports periconceptional folate supplementation to lower congenital heart defect risk; extends NTD prevention evidence to additional birth outcomes.
Does folate supplementation prevent congenital heart defects and low birth weight in pregnant women?
Folate supplementation in pregnant women may protect against congenital heart defects and low birth weight, but evidence does not currently support high-dose regimens over standard recommendations.
Obeid et al. (2019) conducted a review in congenital heart defects and low birth weight. Folate supplementation was evaluated. Folate supplementation in pregnant women protects against congenital heart defects and low birth weight, but no RCTs support doses higher than the recommended 400-800 µg/d.
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